Paclitaxel antitumor effect improvement in lung cancer and prevention of the painful neuropathy using large pegylated cationic liposomes

Abstract Paclitaxel (PTX), a drug widely used in lung cancer, has serious limitations including the development of peripheral neurotoxicity, which may lead to treatment discontinuation and therapy failure. The transport PTX large cationic liposomes could avoid this undesirable effect, improving patient’s prognosis. was encapsulated with two different sizes, MLV (180?200?nm) SUV (80?100?nm). In both cases, excellent biocompatibility improved internalization antitumor effect were observed human mice cancer cells culture, multicellular spheroids stem (CSCs). addition, polyethylene glycol (PEG) shell, induced greater tumor volume reduction than (56.4 % 57.1 vs. 36.7 %, respectively) mice. Interestingly, MLV-PEG-PTX did not induce either mechanical or heat hypersensitivity whereas SUV-PEG-PTX produced similar response free PTX. Analysis distribution showed very low concentration dorsal root ganglia (DRG) MLV-PEG-PTX, but These results support hypothesis that induces neuropathy by penetrating endothelial fenestrations DRG (80?100?nm, measured mice). conclusion, our larger (MLV-PEG-PTX) only biocompatibility, activity against CSCs, vitro vivo activity, also protected from PTX-induced painful neuropathy. advantages be as new strategy chemotherapy increase reduce its side effects.